Frank Lampard takes charge of his first game in the Premier League as Chelsea boss and he has made a few key decisions in his opening game of the Premier League season.
Kurt Zouma and Andreas Christensen pair up at the heart of the Blues' defence, whilst Jorginho and Mateo Kovacic are given the nod in midfield - Kante is on the bench.
Christian Pulisic will start on the bench, and Mason Mount and Ross Barkley both start for the Blues!
Tammy Abraham will lead the line for Frank Lampard's side.
Chelsea's starting XI:
Manchester United's starting XI:
All the action gets underway at Old Trafford from 4:30pm UK time.