Miami quarterback Jarren Williams threw three interceptions in the Hurricanes' first three offensive drives of the game.
Virginia Tech quarterback Hendon Hooker scored a touchdown on the ground to cap off the Hokies' opening drive.
Williams' best offensive play was a 11 yard run. He was benched for the remainder of the game after completing 4-of-7 passes for 47 yards, no touchdowns and three interceptions. He also left the game with -2 rushing yards.
Virginia Tech tight end Dalton Keene caught all three of Hooker's touchdown passes.
The Hurricanes defense were held without a turnover.
N'Kosi Perry took over at quarterback and completed 28-of-47 passes for 422 yards and four touchdowns against one interception.
Miami wide receiver Jeff Thomas caught six passes for 124 yards and a team leading two touchdowns.
Miami linebacker Michael Pinckney led the Hurricanes with 11 tackles.