Hornibrook also sat out last week's loss to Penn State as he continues to deal with concussion-like symptoms that also caused him to miss a game versus Northwestern on Oct. 27.
Although Hornibrook returned the following week against Rutgers he struggled before exiting the game due to concerns about his head injury.
Sophomore Jack Coan is expected to make his third start of the season. Coan had a rough game against Penn State, getting sacked five times, committing four turnovers and completing only 9 of 20 passes for 60 yards.
In a relief effort versus Rutgers, Coan was 5 of 7 for 64 yards and a touchdown. In his start against Northwestern, Coan finished 20 of 31 for 158 yards and a touchdown.
Hornibrook has dealt with concussion issues in the past, missing the 2016 Big Ten Championship Game against Penn State because of a concussion. He also was limited in the Cotton Bowl against Western Michigan that same year after suffering a concussion in the regular-season finale.
In eight games this season, Hornibrook has 11 touchdowns and eight interceptions. He had 21 scoring passes and 15 picks in 13 games in 2017.
Wisconsin (6-4, 4-3 Big Ten) trails Northwestern by two games in the conference's West Division. Purdue enters Saturday's matchup at 5-5, 4-3.