Cook, whose rookie season ended with an ACL tear, will be held out of the game for precautionary reasons, the St. Paul Pioneer Press reported Saturday.
The Vikings have said that Cook is fully healthy and announced before training camp that the second-year back will not face any limitations.
Cook also sat out Minnesota’s preseason opener. Latavius Murray, who took over the starting job after Cook was hurt last season, was expected to start against Jacksonville.
A second-round pick out of Florida State in the 2017 NFL Draft, the 23-year-old Cook burst onto the scene by rushing for 127 yards on 22 carries in his professional debut.
Cook amassed 354 yards rushing on 74 attempts, averaging a robust 4.8 yards per carry, before suffering a torn ACL in Week 4 against the Detroit Lions last season.
The 5-foot-10, 210-pounder scored a rushing touchdown in each of his final two games before he was hurt. He also had 11 receptions for 90 yards.
At Florida State, Cook rushed for over 1,000 yards in each of his three seasons, including a career-high 1,765 yards in 2016.
Cook piled up 46 rushing touchdowns in 38 games for the Seminoles, scoring 19 times on the ground in each of his final two seasons.